A PRELIMINARY COMPARATIVE QUALITY EVALUATION TESTING OF ACETAMINOPHEN TABLET MARKETED IN SAKAKA CITY, SAUDI ARABIA

21-HJPV4(1)-2022 Original Article

Abstract

Acetaminophen is a medication used as an antipyretic and analgesic. It is commonly available as an Over the Counter (OTC). Different dosage forms of acetaminophen are available in the market; we have selected solid dosage form as acetaminophen tablet. The main stressing point of the current study is to evaluate and compare quality control of three brands of acetaminophen tablets available in Sakaka, Saudi Arabia. Each of the sample of having 500mg as an active constituent that was purchased from the local retail pharmacy outlets and their quality evaluation, were assessed by using in-vitro tests according to official monograph of US and BP. The parameter for quality evaluation of the tablet which was studied including content uniformity, weight variations, thickness, hardness, friability, disintegration, and assay and dissolution study according to the given specification of the official monograph. The weight variation, friability, and hardness values of each of the branded tablet were complied with specifications. In-vitro disintegration and dissolution analysis showed that the disintegration time of all three brands was within 15min and dissolution test results represented that more than 80% drug released within 30min. The results represented that the overall finding of the quality control evaluation of all tested brands of acetaminophen tablets that are available in Sakaka city, Saudi Arabia was being observed with the official requirement of USP and BP specification for quality control purposes.