PRELIMINARY STUDIES ON THE PHYSICAL PARAMETERS OF ORODISPERSIBLE TABLETS USING SUPERDISINTEGRANTS

07-HJPV1(1)-2019Original Article

Abstract

There are various routes of drug administration available such as oral, sublingual, inhalation, and rectal. Among all, the oral route of drug administration is most widely used. Tablet is the most popular dosage form among all existing dosage forms. The most conventional tablets are immediate release but these tablets are only suitable for drugs with high solubility and high permeability. In this study, five different Orodispersible tablet formulations were prepared. Various Natural and Synthetic super disintegrants were used in all formulations including Plantago Ovata (F1), Sodium Alginate (F2), Fenugreek (F3), Croscarmellose Sodium (F4) & Crospovidone (F5). Various pre-formulation and post-formulation tests were performed for all five (05) formulations like Angle of repose, Bulk density, Tapped density and Compressibility index. Additionally, all of the prepared formulations were evaluated for weight variation, friability, hardness, drug content, and disintegration time and dissolution rate. Furthermore, stability testing of Risperidone Oro dispersible tablets was conducted. The results revealed that all the formulations F1, F2, F3, F4, and F5 complied with the official specification limits. Among all formulations, F1 showed the best results in terms of less disintegration and increased dissolution of drug as compared to other formulations, and the F1 formulation showed good stability results as well.